Program MCTW
!!! Live stream !!! (#) mctw
Thursday 10th of
October 2024
09:00 Registration
09:30 Opening remarks
SESSION I – BASIC RESEARCH IN MULTIPLE MYELOMA
Chair: Assoc. Prof. Michal Šimíček, PhD
09:40 Composition of Bone Marrow Adipose Tissue in Multiple Myeloma Patients
Zoltán Kellermayer, MD, PhD – Institute of Immunology and Biotechnology, University of Pécs, HU
09:55 Serving or Stealing: Mitochondrial Transfer through Tunnelling Nanotubes in B Cell Malignancies
Narendra Varma Gottumukkala, MSc – Central European Institute of Technology (CEITEC), Masaryk University, Brno, CZ
10:10 Development of Novel anti-BCRG1 Allogenic CAR T-cells
Assoc. Prof. Michal Šimíček, PhD – Blood Cancer Research Group, Ostrava, CZ
10:30 Coffee break
SESSION II – ACADEMIC APPROACH TO CAR T THERAPY
Chair: Prof. Roman Hájek, MD, PhD
10:45 Academic Approach to CAR-T Therapy – Spain Experience
Natalia Tovar, MD (online) – Hospital Clínic de Barcelona, Barcelona, ES
11:00 Update to the Role of Allogeneic Hematopoietic Cell Transplantation in Multiple Myeloma in Poland
Prof. Sebastian Giebel, MD, PhD – Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice, PL
11:15 Academic Approach to CAR-T Therapy in the Czech Republic
Assoc. Prof. Pavel Otáhal, MD, PhD – Institute of Hematology and Blood Transfusion, Prague, CZ
11:30 Setting Up Cell Therapy Production Facility in Ostrava
Sandra Charvátová, MD, PhD – Blood Cancer Research Group, Ostrava, CZ
11:50 Lunch break
SESSION III – PREDICTORS OF TREATMENT RESPONSE IN IMMUNOTHERAPY – CAN WE MOVE ON?
Chair: Jana Mihályová, MD
13:00 The Ideal Sequence of T-Cell Engaging Therapies
Prof. Maximilian Merz, MD, PhD (online) – Department for Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Lepizig, DE
13:15 Monitoring of Anti-BCMA CAR-T Cells and Non-CAR-T Immune Subsets in Multiple Myeloma Patients
Ondřej Venglář, PhD – Blood Cancer Research Group, Ostrava, CZ
13:30 Identifying and Overcoming Mechanisms of Resistance in Multiple Myeloma Patients Receiving Talquetamab
Tarek H. Mouhieddine, MD (online) – Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
13:45 Single Cell Immune Profiling in Patients Undergoing BCMA Therapy
Junia Vieira dos Santos, MD, PhD (online) – Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
SESSION IV – FUTURE PERSPECTIVES IN CAR T-CELL THERAPY
Chair: Piotr Celichowski, PhD
14:05 Development of CAR T-Cells Therapy from Stem Cells
Assoc. Prof. Maria Themeli, MD, PhD (online) – Department of Hematology, Amsterdam UMC, NL
14:20 Development of Nanobodies and Nanobody Based CARs
Prof. Elzbieta Sarnowska, PhD – Maria Skłodowska-Curie National Research Institute of Oncology, PL
14:35 Sensitive and Bispecific Chimeric TCRs for Cancer Therapy
Simon Sylvain, PhD (online) – Fred Hutchinson Cancer Research Center, Seattle, WA, USA
14:50 Current Approaches for Engineering Allogenic CAR T-cells
Piotr Celichowski, PhD – Blood Cancer Research Group, Ostrava, CZ
15:10 Coffee break
SESSION V – NEW PERSPECTIVES ON RARE MONOCLONAL GAMMOPATHIES
Chair: Zuzana Chyra, PhD / Tereza Ševčíková, PhD
15:25 Highly Efficient Genome Editing in Pluripotent Stem Cells under GMP-compatible Conditions and Differentiation into Monocytes/Macrophages
Ruba Hammad, MSc – Institute for Transfusion Medicine and Gene Therapy, University of Freiburg, DE
15:40 Engineering Cells for Cancer Immunotherapy
Assoc. Prof. Quanyin Hu, PhD (online) – Wisconsin Center for NanoBioSystems, University of Wisconsin, Madison, USA
15:55 The Diagnostic Challenge of Waldenstrom Macroglobulinemia
Nicolò Danesin, MD (online) - Hematology Unit, University of Padua, IT
18:00 Social event - Plato Gallery, Ostrava
19:30 Dinner - Hola Tapas Bar, Ostrava
Friday 11th of October 2024
9:00 Poster session for everyone
SESSION VI – CHALLENGES IN BIOINFORMATICS
Chair: David Žihala, PhD, Tereza Ševčíková, PhD
09:30 Unraveling the Diversity and Functions of Tissue-Resident Plasma Cells
Prof. Stephen L. Nutt, PhD (online) – The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, AU
09:45 Resolving the Spatial Architecture of Myeloma and Its Microenvironment at the Single-Cell Level
Prof. Niels Weinhold, PhD (online) – Heidelberg Myeloma Center, Department of Medicine, University Hospital Heidelberg, Heidelberg, DE
10:00 Single-cell RNA Sequencing to Identify Circulating Tumor Cells
Romanos Sklavenitis-Pistofidis, MD, PhD (online) – Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
10:15 Dissecting the Multicellular Ecosystem in Extramedullary Myeloma Using Spatial Transcriptomics
Moutaz Helal, MSc – University Hospital of Würzburg, Würzburg, DE
10:30 Composition and Fitness of T and NK Cells in Extramedullary Myeloma Tumor Microenvironment
Anjana Sithara Anilkumar, MSc – Blood Cancer Research Group, Ostrava, CZ
10:45 Coffee break
11:00 DISCUSSION – CHALLENGES AND ISSUES: Patenting and Licensing of Academic CAR-T Cells
12:00 Closing remarks of the MCTW 2024
12:15 Lunch break